Norwich, New York of the Excellence in Geriatric Pharmacy Practice Award from the Commission for Certification in Geriatric Pharmacy. Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Plaquenil uses Cbd oil and plaquenil Plaquenil and total knee replacement Norethindrone and plaquenil The seizure threshold is a tipping point in a person's brain activity where a seizure will develop. People with seizure disorders tend to have a low seizure threshold, and this can be exacerbated over time, as seizures can have the effect of exciting the brain and increasing the chances of having another seizure. PLAQUENIL is used concomitantly with other arrhythmogenic drugs. Mefloquine and other drugs known to lower the convulsive threshold PLAQUENIL can lower the convulsive threshold. Co-administration. Of the first-generation antipsychotic medications, chlorpromazine appears to be associated with the greatest risk of seizure provocation, although other first-generation antipsychotics also lower seizure threshold. Conversely, molindone, haloperidol, fluphenazine, pimozide and trifluoperazine are associated with a lower risk of seizure induction. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Although not all of these side effects may occur, if they do occur they may need medical attention. Plaquenil lower seizure threshold Plaquenil & other drug interactions ? Lupus Forums at., PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Can you just stop taking plaquenilPlaquenil lichen planopilarisAralen hydrochlorideIs plaquenil used to treat psoriatic arthritis Neuro-Pharmacology Drugs to avoid in patients with seizures 33 Drugs to avoid in patients with seizures - Although the list of medications that lower seizure threshold is huge, most of these medications cause seizures only in rare occasions. Neuro-Pharmacology Drugs to avoid in patients with seizures. Antipsychotic medication and seizures a review.. What causes seizures?. The condition remains underdiagnosed because of underreporting of signs and symptoms. Another reason for lack of treatment is the belief that antidepressants have proconvulsant effects. Many antidepressants are known to lower the seizure threshold; however, data indicate that, at low doses. Hydroxychloroquine can lower the seizure threshold; therefore, the activity of antiepileptic drugs may be impaired with concomitant use. Azithromycin Major Avoid coadministration of hydroxychloroquine and azithromycin. Hydroxychloroquine increases the QT interval and should not be administered with other drugs known to prolong the QT interval. Aug 14, 2017 Tramadol, a powerful narcotic pain reliever, can lower the seizure threshold, reports the medical reference website The likelihood of seizures associated with tramadol use increases in patients concurrently taking antidepressants, antipsychotic medications and other narcotics.