They are most common among people with weak immune systems. People with certain health conditions may need to take medications with side effects that can weaken your immune system and put you at risk for fungal infections. How long does it take plaquenil to leave your system Chloroquine phosphate ich Levaquin reactions with plaquenil If Plaquenil helps, then maybe it is reining the immune system in I don't actually know how it works scientifically. Theoretically, it may make us more vulnerable to external viruses. Also, about having colds and lupus symptoms; I know it's not everyone's experience, but whenever I have a cold, I have fewer lupus symptoms. A lower dose may stop them. Do not lower the dose on your own. Plaquenil stays in your body for about 3 months. If you must stop it, it will take a while for the side effects to go away. You should have an eye examination every year to prevent a very rare but serious eye problem. According to the American College of Rheumatology, hydroxychloroquine Plaquenil, is a “disease-modifying anti-rheumatic drug DMARD,” meaning that it helps reduce the pain and swelling that come with arthritis. It can also reduce the incidence of joint damage, thus lessening the risk of developing a long-term disability from complications of RA. Fungal infections can range from mild to life-threatening. Specifically, corticosteroids and TNF (tumor necrosis factor) inhibitors are two types of medications that can increase your chances of getting a fungal infection. Does hydroxychloroquine lower your immune system Hydroxychloroquine Oral Route Description and Brand Names., Lupus Medicines Hydroxychloroquine - Brigham and Women's. Plaquenil sulfate allergyHydroxychloroquine and charcot marie tooth diseaseHydroxychloroquine and drinking alcohol Howdy LadyDi, sorry you are having problems. Plaquenil is what is call an immune modifier. It is not a immune suppressant. Originally it was used to prevent Malaria. Then it was discovered to be effective for the treatment of Lupus. Plaquenil has the least amount of side affects in treating auto immune disorders. Does Plaquenil supress the immune system?. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. Medications that Weaken Your Immune System and Fungal.. Plaquenil Hydroxychloroquine sulfate is a drug originally used to prevent or treat malaria. Malaria is a serious but rare disease caused by bites from infected mosquitos. Now the drug is used to treat inflammatory diseases. This type of disease occurs when the body's immune system attacks its own healthy tissue. Plaquenil works by suppressing the immune system. Unfortunately you can't tell it to attack just the germs so you suppress all of its function to spare your healthy tissue- in your husband's case, his eyes, mouth, throat. NOTE Plaquinil and hydroxychloroquine are essentially the same drug. The same effects should be expected from both drugs. 2. No, his immune system should not be forever compromised. Hydroxychloroquine and the immune system. Just wondered if anyone can tell me whether hydroxy suppresses the immune system. And if so, to what extent. I know it's not as harsh as some of the other drugs but just wondered what people's experiences are.