Antibodies directed against the 65-kd isoform of GAD (GAD65) are seen in a variety of autoimmune neurologic disorders including stiff-man (Moersch-Woltman) syndrome, autoimmune cerebellitis, brain stem encephalitis, seizure disorders, neuromyelitis optica and other myelopathies, myasthenia gravis, Lambert-Eaton syndrome, and dysautonomia. GAD65 antibody is also the major pancreatic islet antibody and an important serological marker of predisposition to type 1 diabetes. Hydroxychloroquine 200 mg tab tablet Treatment rheumatoid arthritis with methotrexate and hydroxychloroquine Chloroquine autophagy mice In the context of diabetes, GAD65 antibodies have been associated with an infectious etiology, especially entero and coxsackie viruses. 4,5 However, GAD65 antibodies interestingly bear a striking similarity with P2-C protein of coxsackie virus suggesting a cross-reactivity and interference with neuronal development. Objective Antibodies against glutamic acid decarboxylase 65 anti-GAD65 are associated with a number of neurologic syndromes. However, their pathogenic role is controversial. Our objective was to describe clinical and paraclinical characteristics of anti-GAD65 patients and analyze their response to immunotherapy. Methods Retrospectively, we studied patients n = 56 with positive anti-GAD65. Original Article Influence of magnolol on GAD67 and GAD65 in the hippocampus of rats with epilepsy-depression comorbidity Juanjuan Shi 1, Jiarui Zhang2, Zhuo Yuan 1, Li Shen, Hong Yan 1Department of Psychology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin GAD65 antibodies are found in the serum of approximately 8% of healthy subjects older than age 50, usually in low titer, but often accompanied by related "thyrogastric" autoantibodies. GAD65 autoantibody also serves as a marker of predisposition to other autoimmune disease that occur with type 1 diabetes, including thyroid disease (eg, thyrotoxicosis, Grave disease, Hashimoto thyroiditis, hypothyroidism), pernicious anemia, premature ovarian failure, Addison disease, (idiopathic adrenocortical failure) and vitiligo. Scholarly articles plaquenil gad65 Su.22. Longitudinal Analysis of Autoantibodies to Gad65 in., Neurologic syndromes related to anti-GAD65 Neurology. Plaquenil insert The glutamic acid decarboxylase 65‐kilodalton isoform GAD65 antibody is a biomarker of autoimmune central nervous system CNS disorders and, more commonly, nonneurological autoimmune diseases. Type 1 diabetes, autoimmune thyroid disease, and pernicious anemia are the most frequent GAD65 autoimmune associations. GAD65 neurological autoimmunity - McKeon - 2017 - Muscle &.. Original Article Influence of magnolol on GAD67 and GAD65 in.. Expression of recombinant glutamic acid decarboxylase in.. Jun 16, 2015 To the best of our knowledge, this is the first time that levels of endogenous GAD65 and GAD65-GADA complexes have been recorded and proven to be significantly elevated in sera from SPS patients. The following article describes an initiative to decrease costs associated with diagnosing type 1 diabetes through the use of selective antibody testing. Targeting IA-2 and GAD65 as a Cost-Saving Approach for Antibody Testing in Children With New-Onset Diabetes Clinical Diabetes The 65-kD isoform of glutamic acid decarboxylase GAD65 is a major autoantigen in type 1 diabetes. We hypothesized that alum-formulated GAD65 GAD-alum can preserve beta-cell function in patients with recent-onset type 1 diabetes.