Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine autophagy concentration Plaquenil help trans myelitis Methotrexate trexall and hydroxychloroquine plaquenil Lc3b chloroquine Chloroquine CQ, the worldwide used anti-malarial drug, has recently being focused as a potential anti-cancer agent as well as a chemosensitizer when used in combination with anti-cancer drugs. The antimalarial agent chloroquine has been found to mitigate some of these challenges by modulating cancer cells and the tissue microenvironment. Particularly, chloroquine was recently found to reduce immunological clearance of nanoparticles by resident macrophages in the liver, leading to increased tumor accumulation of nanodrugs. Aug 19, 2014 Where and How Chloroquine Fights Cancer. Chloroquine is an antimalaria drug that also suppresses tumor growth and metastasis. Chloroquine neutralizes the pH of intracellular compartments, thereby disrupting the endosomal trafficking and lysosomal function. Whereas chloroquine impairs autophagy and proliferation in tumor cells, Maes et al. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Chloroquine and liver cancer Chloroquine inhibits hepatocellular carcinoma cell growth., Chloroquine and nanoparticle drug delivery A promising. Side effects of hydroxychloroquine for raWhat are the side effects from stopping taking plaquenilIs plaquenil safe in pregnancyPlaquenil for raynaud' Realizing that profuse activation of autophagy may contribute to pancreatic tumor growth, researchers designed an experiment in which they planned to treat the pancreatic cancer cell lines with Chloroquine, already known as inhibitor of autophagy. As a control, chloroquine was also used to treat normal cell lines with low expression of autophagy. Chloroquine and Cancer Treatment - Biomedical Research, A.. Where and How Chloroquine Fights Cancer Science Signaling. Chloroquine in Cancer Therapy A Double-Edged Sword of Autophagy. Signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes. Signs of low blood sugar like dizziness, headache, feeling sleepy, feeling weak, shaking, a fast heartbeat, confusion, hunger, or sweating. Chloroquine enters the red blood cell by simple diffusion, inhibiting the parasite cell and digestive vacuole. Chloroquine then becomes protonated to CQ2+, as the digestive vacuole is known to be acidic pH 4.7; chloroquine then cannot leave by diffusion. Chloroquine inhibits NETs and diminishes hypercoagulability. These findings support clinical study of chloroquine to lower rates of venous thromboembolism in patients with cancer.