Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Chloroquine nurses responsibility Can you take plaquenil if you are allergic to sulfa Chloroquine as antiinflammatory Hydroxychloroquine bleeding and surgery Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Concomitant renal or liver disease because the drug is cleared by both routes underlying retinal disease or maculopathy ; age greater than 60 years. Monitoring Guidelines. Guidelines on screening for retinopathy associated with hydroxychloroquine toxicity were initially published by the Academy in 2002. PLAQUENIL film-coated tablets cannot be divided, therefore they should not be used to treat patients who weigh less than 31 kg. For radical cure of P. vivax and P. malariae infections, concomitant therapy with an 8-aminoquinoline compound is necessary. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Plaquenil creatinine Plaquenil Side Effects Common, Severe, Long Term -, Hydroxychloroquine-Induced Retinal Toxicity - American. Primaquine and chloroquine are drugs used in the treatment infectionsHydroxychloroquine mechanism of action drunkbankHydroxychloroquine and sle A small retrospective study on 118 patients with rheumatoid arthritis reported that 55% of patients receiving chloroquine and 15% of those receiving hydroxychloroquine showed a 10% decrease of creatinine clearance after the start of antimalarial drugs. Hydroxychloroquine Use and Risk of CKD in Patients with.. Plaquenil Dosage Guide -. Plaquenil hydroxychloroquine sulfate dose, indications.. Plaquenil increases the pH of lysosomes and impairs complement-dependent antigen-antibody reactions. It also inhibits the chemotaxis of eosinophils and locomotion of neutrophils. SUMMARY OF EVIDENCE in development Ponticelli C et al. 2017 “Hydroxychloroquine in systemic lupus erythematosus SLE” Expert Opin Drug Saf. Mar; 163411-419. Renal clearance in rheumatoid arthritis patients taking PLAQUENIL for at least six months seemed to be similar to that of the single dose studies in volunteers, suggesting that no change occurs with chronic dosing. Range for renal clearance of unchanged drug was approximately 16 to 30% and did not correlate with creatinine clearance; therefore. Plaquenil is not effective against chloroquine or hydroxychloroquine-resistant strains of Plasmodium species see CLINICAL PHARMACOLOGY – Microbiology. Plaquenil is not recommended for the treatment of malaria acquired in geographic areas where chloroquine resistance occurs or when the Plasmodium species has not been identified.