Why chloroquine is given in loading dose

Discussion in 'Canada Pharmaceuticals Online' started by webworm, 17-Mar-2020.

  1. ibadm User

    Why chloroquine is given in loading dose


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    These findings support the idea that a loading dose of 20 mg/kg given at intervals during the first 12 h is well tolerated and can be used to obtain a more rapid decrease in parasitemia and to shorten the treatment time of uncomplicated chloroquine-susceptible falciparum malaria in the field. Where complete treatment of severe malaria is not possible but injections are available, give adults and children a single intramuscular dose of artesunate, and refer to an appropriate facility for further care. Where intramuscular artesunate is not available use intramuscular artemether or, if that is not available, use intramuscular quinine. If a diabetic patient being treated with an oral hypoglycemic agent,develops dilutional hyponatremia-which one of the following could be responsible for this effect

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Why chloroquine is given in loading dose

    Loading dose - Wikipedia, TREATMENT OF SEVERE MALARIA - Guidelines for the Treatment of.

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  3. What I’m wondering is if there is any relationship with increasing the loading dose and the time taken to reach the steady state. For example, if a greater loading dose was given for a particular drug, would this decrease the time taken to reach the steady state compared to smaller loading dose? Thank you very much in advance. Kind Regards, Sarah

    • What is a Loading Dose? – Certara.
    • Chloroquine given in 600 mg as loading dose for.
    • Chloroquine Aralen - Side Effects, Dosage, Interactions - Drugs.

    Inappropriate loading dose reduction resulting in ineffectively low plasma concentration is a significant danger in patients with renal impairment. A single loading dose of antibiotic, equivalent to the usual maintenance dose for patients with normal renal function, should almost always be given to patients with impaired renal function. Usual Adult Dose for Malaria Prophylaxis. 500 mg chloroquine phosphate 300 mg base orally on the same day each week Comments-If possible, suppressive therapy should start 2 weeks prior to exposure; if unable to start 2 weeks before exposure, an initial loading dose of 1 g chloroquine phosphate 600 mg base may be taken orally in 2 divided doses, 6 hours apart. Some medicines need to be given at high initial doses loading doses at the start of treatment, before being reduced to a lower, maintenance dose. Reasons vary for the need for loading doses. In some patients the therapeutic level is needed very quickly—for example, phenytoin to stabilise a patient after a seizure.

     
  4. Legendncit User

    I was planning on potentially going to my pharmacy to buy chloroquine in case the drug is hit with supply issues in the future. Guidelines for Treatment of Malaria in the United States Based on. Chloroquine C18H26ClN3 - PubChem Quinine vs Chloroquine - What's the difference? WikiDiff
     
  5. Dimaman User

    Chloroquine Phosphate - Fish Medication Information Coral. May 22, 2019 What It Treats – Marine Ich Cryptocaryon irritans, Marine Velvet Disease Amyloodinium ocellatum, Brooklynella hostilis and Uronema marinum. How To Buy – Chloroquine phosphate CP is an antimalarial drug for humans which also treats external parasites that afflict marine fish and possibly freshwater fish as well. However, there are a few challenges to overcome with CP.

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