Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it. Plaquenil and effects on growing fetus Efectos de hydroxychloroquine en la vista Medications that can be used for the treatment of malaria in pregnancy include chloroquine, quinine, atovaquone-proguanil, clindamycin, mefloquine avoid in first trimester, sulfadoxine. Chloroquine crosses the placenta and is also found in low levels in breast milk, so pregnancy and lactation are often listed as contraindications to its use see DermNet NZ’s pages on Safety of medicines taken during pregnancy and on Lactation and the skin. However, effects on the fetus and baby have been rarely reported and chloroquine has. Chloroquine, although grouped with hydroxychloroquine in table 2 of this article, is not routinely used in the management of SLE either in or out of pregnancy due to increased tissue deposition and increased risk of retinal toxicity and of fetal abnormalities 10 - 11. The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead. Chloroquine treatment in pregnancy Chloroquine - an overview ScienceDirect Topics, Chloroquine DermNet NZ Can taking plaquenil increase chances of getting sick Alternative drugs to chloroquine are required to prevent the deleterious effects of malaria in pregnancy. Fear of potential toxicity has limited antimalarial drug use in pregnancy. Animal toxicity studies have documented teratogenicity when antimalarials are administered at high dosages. Excepting the tetracyclines, there is no evidence to suggest that, at standard dosages, any of the. The Safety of Antimalarial Drugs in Pregnancy SpringerLink. Treatment of SLE in pregnancy and use of Chloroquine The BMJ. Chloroquine - FDA prescribing information, side effects and uses. Usage in Pregnancy. Usage of chloroquine during pregnancy should be avoided except in the prophylaxis or treatment of malaria when the benefit outweighs the potential risk to the fetus. Radioactively tagged chloroquine administered intravenously to pregnant pigmented CBA mice passed rapidly across Summary. Aralen is the brand name for the generic drug chloroquine, an anti-malaria drug used to treat malaria and amebiasis infection that's spread outside of the intestines. Dosage, drug interactions, and pregnancy and breastfeeding safety information should be reviewed prior to taking this drug. There are no adequate and well-controlled studies evaluating the safety and efficacy of chloroquine in pregnant women. Usage of chloroquine during pregnancy should be avoided except in the suppression or treatment of malaria when in the judgment of the physician the benefit outweighs the potential risk to the fetus. REFERENCES. 1.