Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil et psoriasis Is hydroxychloroquine sulfate an immunosuppressive drug O hydroxychloroquine Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Rarely, hydroxychloroquine can lead to anemia in some individuals. Nov 18, 2013 Hi I think that Lucy may be correct in that the constipation may be caused from your Lupus. Normally, Plaquenil causes the opposite effect with diarrhea being the problem. I've not heard of anyone mentioning constipation as the side effect. That's not to say it doesn't happen though. I would contact your Rheumy and see what they have to say. Plaquenil may interact with Cymbalta and may reduce the effectiveness of methotrexate. Magnesium should also be taken 4 hours apart because it also affects the way the body absorbs the Plaquenil. It can also affect the body's vitamin d levels. Taking B6 with Plaquenil can get rid of skin nodules associated with RA. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. How to reverse the side gastrointestinal side effects of plaquenil Plaquenil Side Effects Go Away? DailyStrength, Bad Side Effects of Plaquenil - Preferred practice patterns plaquenil That said, my doctor had originally prescribed for me to take 100mg/day for one week and then increase to 200mg/day. When I increased to 200mg/day, I had strange side effects that caused me to go back to 100/day. Strange leg cramping, restless leg, nausea and anxiety. In a nutshell, at 200mg/day the side effects outweighed the benefits. PLAQUENIL Side Effects, Reviews by Patients -. Starting Plaquenil DailyStrength. Plaquenil Side Effects Common, Severe, Long Term -. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. No treatment to reverse chloroquine or hydroxychloroquine toxicity. Recommend cessation of the medication, but visual function rarely recovers, especially in the later stages of the disease. Continued deterioration in visual function can occur for a year after discontinuing hydroxychloroquine, possibly due to slow clearance of the medication from the retina and body. Jan 11, 2012 I have been on the plaquenil 200 mgm for about 4 months now. I did stop it for 2 weeks early in the treatment due to having to take a coupld other drugs that seemed to give me side effects. I just quit the plaquenil to give my liver a rest at that time. Noticed nothing different. Plaquenil isn a antiparasitic drug with anti-inflammatory affect.