Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. What is hydroxychloroquine 400 mg used for Plaquenil weight gain loss Can plaquenil help osteoarthritis Chloroquine diphosphate lysosome Increased serum level of liver enzymes is a common finding in patients with systemic lupus erythematosus SLE. Hepatotoxic drugs, viral hepatitis and fatty liver are thought to be the main causes of hepatic lesion in these patients. I am another one with a diagnosis of UCTD. My symptoms most resemble lupus, but positive ANA is the only specifically associated test that is consistantly positive, other than off and on elevations in Sed rate, CRP and liver enzymes. I had one very mildly positive rheumatoid factor. I've been on Plaquenil for 3 years. Plaquenil Hydroxychloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Plaquenil and liver enzymes Will you have Elevated liver enzymes with Plaquenil., Plaquenil - Can i take zyrtec with plaquenilHydroxychloroquine liver toxicity alcohol Liver enzyme abnormality was defined as a 10-fold or greater increase in aspartate aminotransferase and alanine aminotransferase. Acute toxic hepatitis was diagnosed, which rapidly returned to normal after cessation of the suspected causative medication, hydroxychloroquine, and subsequent administration of mycophenolate mofetil. Hydroxychloroquine-induced toxic hepatitis in a patient.. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Elevated liver enzymes - Mayo Clinic. We study how severe was Elevated liver enzymes, when it was recovered, drug effectiveness, race, and more among people who take Plaquenil. This study is created by eHealthMe based on reports of 1,993 people who have side effects when taking Plaquenil from sources other than FDA, and is updated regularly. Core tip The existence of liver disease associated with lupus itself, or increased susceptibility to concomitant liver diseases, either autoimmune or non-autoimmune ones, is still somewhat controversial, and difficult to diagnose. Data in the literature are scarce, and often based on case reports or clinical studies with limited patient size or histological evidence. The doctor just phoned and said my liver enzymes are up and to defintately stop the Plaquenil. I am so disappointed, I am not sure where to go from here. My rheumatologist is not back until the 15th, he was hoping the Plaquenil wouldn't cause any problems.