In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Prednisone plaquenil Oct testing in plaquenil macular toxicity Plaquenil tablets side effects What happens if you stop taking plaquenil Aug 29, 2014 Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. The preferential loss of photoreceptor IS/OS junction makes SD-OCT an ideal tool to identify early changes associated with Plaquenil retinal toxicity. Due to the capabilities of SD-OCT to enhance the structural assessment of the retina, it has allowed for the detection of early damage prior to funduscopic clinical findings. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil retinal toxicity oct Expanded spectral domain-OCT findings in the early detection., How to Succeed in Plaquenil Screenings Plaquenil generic contraindicatedChloroquine resistance in p vivaxPlaquenil altitude sickness Sep 15, 2014 Stepien KE, Han DP. Spectral-domain optical coherence tomography and adaptive optics may detect hydroxychloroquine retinal toxicity before symptomatic visual loss. Trans Am Ophthalmol Soc. 2009; 1–34. PMC free article Retinal toxicity associated with chronic exposure to.. Recommendations on Screening for Chloroquine and.. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy. Nov 01, 2007 The FA appears normal, and the OCT is likewise normal. In addition to topiramate, several related medications generally containing sulfa may induce a similar syndrome of transient myopia, nonpupillary block-angle closure, and retinal folds. Again, the underlying mechanism is thought to be ciliary body swelling. Ocular findings of HCQ retinal toxicity as detected by various screening modalities. A female patient was diagnosed with HCQ retinal toxicity at the age of 53 years, having taken HCQ for 12 years at 400 mg/day. She was not obese and had no additional risk factors for toxicity. Clinically, this manifests as a bulls-eye maculopathy, although these fundus changes are evident only in the later stages of disease Figure 1. The mechanism of toxicity is unknown but is thought to be due to accumulation of the medication in the retinal pigment epithelium RPE.