Please review the following URL and make sure that it is spelled correctly. Hi - I just started Plaquenil (400 mg a day) two week ago and I started feeling less achy and tired a few days ago. Why is hydroxychloroquine important in the treatment of lupus Chloroquine retinopathy oct Plaquenil and your eyes. A rare side effect of Plaquenil is damage to the eye's retina. The retina is the light-sensitive tissue at the back of the eye. Using Plaquenil for a long period of time may harm the retina, causing serious vision loss. People with retinal damage from Plaquenil are not aware at first that they are losing vision. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Mar 24, 2011 Had headaches with the plaquenil so went to the sulfar and predisone. Sulfar was a waste of time and since I had a little help from the plaquenil he switched me back to that with pain meds for the headaches and body. Recently i went back for app. and plaquenil had stopped doing anything so he added the methotrexate to it. I did not want to take it. I've heard it can take months, but I must say that I haven't felt like this since I was a kid - not achy or stiff. Is it possible for it to work quicker in some people? Does plaquenil work Plaquenil Uses, Dosage & Side Effects -, Lupus Medicines Hydroxychloroquine - Brigham and Women's. Plaquenil liver enzymes Hydroxychloroquine Plaquenil is used to treat malaria, lupus, and rheumatoid arthritis. Learn about side effects, warnings, dosage, and more. Hydroxychloroquine Side Effects, Dosage, Uses, and More. What next if plaquenil doesn't work? -. How effective is Plaquenil for Osteoarthritis by duration.. What is hydroxychloroquine Plaquenil, and how does it work mechanism of action? Hydroxychloroquine is classified as an anti-malarial drug. It is similar to chloroquine and is useful in treating several forms of malaria as well as lupus erythematosus and rheumatoid arthritis. Its mechanism of action is unknown. Aug 14, 2017 Plaquenil can cause serious side effects when used in high doses for chronic diseases such as RA over the long term. The New Zealand Dermatological Society recommends that to decrease the risk of retina damage, no more than 200mg of Plaquenil should be taken a day, and a dose of 400mg per day should be taken no longer than a few weeks. Which is what its supposed to do. I went additionally on Imuran about 8 weeks ago and have had more drastic symptom reduction, but that's because Imuran is an immune suppressants whereas plaquenil is an immune modulator/anti malarial. As a heads up plaquenil took 14 weeks for me to feel the full effects.