Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking digoxin: More common Some side effects of digoxin may occur that usually do not need medical attention. Chloroquine retinopathy screening Chloroquine and breast cancer Does hydroxychloroquin cause low wbc Plaquenil thru prime therapeutics Digoxin is one of the oldest cardiac medications still in use. Both the current Canadian guidelines for heart failure and atrial fibrillation and the American College of Cardiology Foundation–American Heart Association guideline for the management of heart failure include digoxin as a treatment option. 1 – 3 However, it does not have the most favourable efficacy and safety profiles. 4, 5. Although the serum digoxin concentration does predict the likelihood of toxicity 11, several conditions increase sensitivity to digoxin. They at least partly account for patients who develop digoxin toxicity when their serum digoxin concentration is within the therapeutic range 12. Dermatologic Effects Dermatologic reactions to PLAQUENIL may occur and, therefore, proper care should be exercised when it is administered to any patient receiving a drug with a significant tendency to produce dermatitis. Drug Interactions. Digoxin Concomitant PLAQUENIL and digoxin therapy may result in increased serum digoxin Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. These side effects may go away during treatment as your body adjusts to the medicine. Lanoxin (digoxin)." Glaxo Wellcome, Research Triangle Park, NC. Does chloroquine increase the effects of digoxin Chloroquine MedlinePlus Drug Information, Digoxin toxicity signs & symptoms, causes, ECG, diagnosis and. History of chloroquine phosphateHydroxychloroquine dialysis Taking digoxin with hydroxychloroquine may increase the levels of digoxin in your body. This may increase your risk of side effects from digoxin. Insulin and other diabetes drugs. Hydroxychloroquine Side Effects, Dosage, Uses, and More. PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION. Chloroquine - FDA prescribing information, side effects and uses. It also crosses the placenta with clinical effects bradycardia noted sometimes in newborns. Approximately 25% of digoxin is protein bound. Digoxin does have some trivial hepatic metabolism 20% and this is not dependent on the cytochrome 450 system, nor does digoxin up or down regulate this enzyme pathway. Some side effects of digoxin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Chloroquine may increase the effects of digoxin. Antimalarials are not compatible with heart medications. Chloroquine may increase the effects of digoxin.