Hydroxychloroquine is available as the brand-name drug Plaquenil. Generic drugs usually cost less than the brand-name version. Hydroxychloroquine may be used as part of a combination therapy. Chloroquine poisoning treatment What is chloroquine in lysosomes Discussion. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a patient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Aug 30, 2011 Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. Hydroxychloroquine is used to treat lupus erythematosus and rheumatoid arthritis. It isn’t fully understood how this drug works to treat lupus erythematosus or rheumatoid arthritis. That means you may need to take it with other drugs. It treats malaria by killing the parasites that cause the disease. Plaquenil overdose Despite Plaquenil dosing recommendations, retinal toxicity., Hydroxychloroquine-Induced Retinal Toxicity - American. Metabolic fate of chloroquinePlaquenil lfts Apr 10, 2019 Plaquenil overdose must be treated quickly. You may be told to induce vomiting right away at home, before transport to an emergency room. Ask the poison control center how to induce vomiting in the case of an overdose. Overdose symptoms may include drowsiness, vision changes, slow heart rate, chest pain. Plaquenil Uses, Dosage & Side Effects -. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Plaquenil Dosage Guide -. Plaquenil-induced toxicity usually will not occur before five years of taking the drug. “Eye damage due to Plaquenil is not common,” he says. “Rarely will anybody who has good vision and minimal symptoms develop loss of central vision or ability to read if annual screening is done and visual are symptoms reported as soon as they occur so the medication can be stopped if toxicity occurs. Jun 30, 2015 Plaquenil Overdose Back to Top If you take too much Plaquenil, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away. Overdose symptoms may include Headache. Drowsiness. Vision changes. Slow heart rate. Chest pain or heavy feeling. Pain spreading to the arm or shoulder. Nausea. Sweating. Seizure. Shallow breathing. Breathing that stops.