Additionally, another exception occurred while executing the custom error page for the first exception. Download PDF Many systemic medications may cause retinal toxicity. Chloroquine resistant plasmodium falciparum Chloroquine torsades Is hydroxychloroquine used for pain Symptoms of hydroxychloroquine Hydroxychloroquine is a well-tolerated medication for various rheumatologic and dermatologic conditions. Its main side effects are gastrointestinal upset, skin rash, headache, and ocular toxicity1. Within the eye, hydroxychloroquine can adversely impact the cornea, ciliary body, and retina1 Provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. Plaquenil toxicity guildeline Despite Plaquenil dosing recommendations, retinal toxicity., Plaquenil Dosage Guide - Plaquenil color vision effectsPlaquenil and contraceptive pillLong term side effects of plaquenilPlaquenil dosage based on weightHow does plaquenil affect sleep The more likely they are to develop toxicity However, there is an extremely low chance of toxicity within the first five years of usage of the drug Revised guidelines recommend19 • Baseline examination within first year of usage of Plaquenil Hydrochloroquine or Aralen Chloroquine • Annual screening after 5 years of use Early Plaquenil Toxicity Detected without Bull’s Eye.. Chloroquine and Hydroxychloroquine Toxicity Guidelines.. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of. Although the incidence of macular toxicity is infrequent with Plaquenil use at a dosage of 200mg or 400mg q.d. its visual impact can be devastating. 2,3. The associated classic retinal toxicity is described as a bull’s eye maculopathy ring of depigmented retinal pigment epithelium that spares the foveal area. Guidelines on screening for retinopathy associated with hydroxychloroquine toxicity were initially published by the Academy in 2002. These guidelines were updated in February of this year, given the emergence of more sensitive diagnostic techniques and the recognition that risk of toxicity from years of hydroxychloroquine use is greater than.