At first it seemed like it helped now I feel the same as before I started taking the medicine other than the fact that none of my clothes fit and there is a lot more of me to carry around. Anyone know if I quit taking it if the weight will fall back off I started Hydroxychloroquine 2 weeks ago. One week in and I thought this may just work, except for the ‘extra itchiness’ I seemed to get every night. Plaquenil is os junction Plaquenil lupus nephritis What does chloroquine do in gel Chloroquine sigma ready made Re Plaquenil not working anymore Lizzy, I took 400mg 200 twice a day for 16-18 months forget exact duration, then was reduced to 200 mg daily. But right from the start, I also needed NSAID's for pain. Hydroxychloroquine does not work straight away. It may take 8 to 12 weeks for symptoms to start to improve. The full effect of treatment may take up to 26 weeks. Generally, hydroxychloroquine is given in 200 mg or 400 mg doses, once per day. Higher doses can sometimes be used, but only in adults and not for all cases. Some people tolerate this medication much better than other people, so it is important that individuals who are considering taking hydroxychloroquine talk with their doctor about the lowest necessary dose to reduce or eliminate their symptoms. I was prescribed this drug to ease my ra disease, I was taking 400mg per day which was to last for 3 months then reduced to 200mg. Right before I hit the two week mark, I woke up with my heart racing and continued feeling my heart flutter all day and I just felt week and tired. After msging Rheum, decided to stop taking meds to see how I feel and continue with the AIP to handle symptoms and try to work at ‘healing from inside out! Time will tell and I’m eager to see how much the AIP is helping once odd meds. Hydroxychloroquine not working What next if plaquenil doesn't work?, Hydroxychloroquine — Arthritis Australia Plaquenil eyes side effectsHydroxychloroquine dose aaoChloroquine cancer HOW IT WORKS It is not clear why hydroxychloroquine is effective at treating autoimmune diseases. It is believed that hydroxychloroquine interferes with communication of cells in the immune system. How does Plaquenil work?. RA and Hydroxychloroquine How Effective is it for Rheumatoid.. Signs Your RA Treatment Isn't Working. Hydroxychloroquine does not work immediately and it may be 12 weeks or longer before any benefit is noted. When should I take hydroxychloroquine? You should take hydroxychloroquine with or immediately after food. What dose should I take? Your doctor will advise you about this. Usually you will be started on a full dose for example, 400 mg. If Plaquenil doesn't work. Discussion in 'Medications' started by superloopie, Oct 22, 2009. superloopie Registered. I have been on the plaq since about June- 400 mg a day since early july. At first I was feeling much better, but that has changed. I have more and more fluid build up in my hands and wrists and the fatigue is strong again. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. Hydroxychloroquine belongs to a group of medicines known as antimalarials. It works by preventing or treating malaria.