Chloroquine-resistant malaria is now widespread in africa

Discussion in 'Chloroquine Pills' started by zolotov_denis, 01-Mar-2020.

  1. nineinchnail Moderator

    Chloroquine-resistant malaria is now widespread in africa


    Previously referred to as “Resochin”, Chloroquine was first discovered in 1924 at Bayer laboratories. Its first use was initially ignored as it was found to be toxic to people.

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    Antimalarial drug use in Africa. Malaria remains an overwhelming problem in Africa, where about 90% of global malaria morbidity and mortality occur. 1 In most of sub-Saharan Africa, the majority of cases are caused by Plasmodium falciparum, the most virulent human malaria parasite, and the parasite with the greatest likelihood of drug resistance. Chloroquine resistance that first emerged in Southeast Asia in the 1950s eventually reached sub-Saharan Africa in the 1970s. The spread of chloroquine-resistant falciparum malaria in Africa was responsible for a sharp increase in malaria morbidity and mortality 2, 3. From the late 1950s to the 1970s, chloroquine-resistant malaria parasites spread across Asia to Africa, leading to a resurgence of malaria cases and millions of deaths. Chloroquine was replaced by.

    These trials showed that chloroquine eliminated malaria and was appropriate to be used as an antimalarial drug. Thus, it was not until World War II that the government of the United States sponsored the clinical trials of chloroquine as an antimalarial drug.

    Chloroquine-resistant malaria is now widespread in africa

    Malaria Travel & Health Guide, 2019 Online Book, The return of chloroquine-susceptible. - Malaria Journal

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  5. Drug resistance in Africa versus Asia. While chloroquine-resistant malaria was rapidly outcompeted after the removal of chloroquine as the first-line treatment in Malawi, a similar return of chloroquine-susceptible infections has not been observed in Asia. The uniqueness of this phenomenon in Africa, but not in Asia, is likely multi-factorial.

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    Chloroquine-resistant P. vivax malaria was first identified in 1989 among Australians living in or traveling to Papua New Guinea. P. vivax resistance to chloroquine has also now been identified in Southeast Asia, Ethiopia, and Madagascar. Isolated reports have suggested chloroquine-resistance P. vivax in other countries and regions, but further evaluation is needed. FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of limited value. For the last decade chloroquine-resistant Plasmodium falciparum CRPF has spread explosively in sub-Saharan Africa. In some areas of the continent, CRPF is so intense that chloroquine can hardly be said to have any efficacy.

     
  6. karpov Moderator

    Hydroxychloroquine is used to prevent or treat malaria infections caused by mosquito bites. Antacids Types, Precautions, Side Effects & More Proton Pump Inhibitor PPI Interactions Drugs, Foods & Drinks Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  7. Reg.ru Well-Known Member

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Medicines for the Prevention of Malaria While. - cdc.gov Chloroquine MedlinePlus Drug Information Apetamin Side-effects and Precautions PLEASE READ THOROUGHLY.
     
  8. xhan Guest

    Plaquenil Hydroxychloroquine - Side Effects, Dosage. What Is Plaquenil Hydroxychloroquine? Plaquenil is the brand name for the prescription drug hydroxychloroquine. It's used to treat and prevent malaria infection, and to reduce symptoms and.

    Medicines for the Prevention of Malaria While Traveling.