Had symtoms of malar rash, joint pain especially in hands, fatigue , dry eyes and dry skin . Had a biopsy of skin and confirmed cutaneous lupus. I was put on Plaquenil and for the past 8 years I have been fine with it . Now this year I have been having things pop up that are related to a low immune system. Chloroquine for sale Difference between hydroxychloroquine and methotrexate Hydroxychloroquine Plaquenil is an antimalarial drug that also has anti-inflammatory qualities and is used to treat certain autoimmune diseases, including rheumatoid arthritis and Sjögren’s disease. Hydroxychloroquine is take orally by mouth. Common side effects include vomiting, headache, changes in vision, and muscle weakness. My LLMD just precribed Plaquenil to me. so far so good tho I am concerned about the Vision issues with this medication but from everything I read its very rare to have Vision problems and nothing I read said that it was an Immune suppressant. Howdy LadyDi, sorry you are having problems. Plaquenil is what is call an immune modifier. It is not a immune suppressant. Originally it was used to prevent Malaria. Then it was discovered to be effective for the treatment of Lupus. Plaquenil has the least amount of side affects in treating auto immune disorders. Does anybody have any input concerning taking Plaquenil for long term therapy ? Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack . I tried to only take 100 mg to see if it would make a difference but I started with terrible joint pain and fatigue so I am back on the 200 mg a day. Hydroxychloroquine immune suppressant Does hydroxychloroquine suppress the immune system - Answers., Is Plaquenil an immumo-suppressant? Stopping plaquenil medicationPlaquenil for iga nephropathyChloroquine diphosphate e coli All of my symtoms pretty much cleared up. Now this year I have been having things pop up that are related to a low immune system. Some of my doctors think It is the Plaquenil causing it but then some say that Plaquenil is not an immunosuppressant drug that for some reason my immune system is out of wack. I only take 200 mg a day. Is Plaquenil a immunosuppressant drug ? Autoimmune.. Does Plaquenil supress the immune system?. Hydroxychloroquine and the immune system Hi everyone.. Dosage for Plaquenil. The adult dose of Plaquenil to suppress malaria is 400 mg on the same day each week. The pediatric weekly suppressive dosage is 5 mg/kg of body weight. The adult dose of Plaquenil to treat an acute attack of malaria is an initial dose of 800 mg followed by 400 mg in six to eight hours and 400 mg for two more days. Hydroxychloroquine Plaquenil Is An Tl, et al. 2017Hu SC, et al. 2016ConclusionReference As with other drugs that may suppress your immune system, talk to your doctor about any vaccines or surgeries you may have. In addition, be sure to notify him/her of any other medications, both prescription and over-the-counter, that you may be taking.