In the UK an estimated 8.5 million people are affected by OA, causing an enormous burden to health authorities, as well as considerable pain and disability to these individuals. A recent study by Arthritis Care reported that 81% of people with OA experience constant pain and 72% have important related conditions, such as high blood pressure or depression. Oct of plaquenil toxicity How does hydroxychloroquine work for lupus HERO was designed as an investigator-initiated multicentre, randomized, double-blindplacebo-controlled trial to compare the analgesic efficacy of hydroxychloroquine in painful hand OA. Participants will be randomized on a 11 basis to hydroxychloroquine or placebo. HERO Trial - Hydroxychloroquine Fails in Hand Osteoarthritis. UK researchers have treated 248 patients with moderate to severe hand pain and radiographic osteoarthritis OA and demonstrated no benefit after 12 months of hydroxychloroquine HCQ, according to a recent article in Annals of Internal Medicine. Mar 17, 2019 Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. However, despite the prevalence of hand OA, there are still limited treatment options. Hand OA is generally considered to be less important and less disabling than knee or hip OA, but 8% of the UK population are estimated to be effected by painful hand OA, with a large proportion reporting significant difficulties with common day-to-day tasks, leading to reduced capacity to work and impacting on both quality of life and general health. Hero study hydroxychloroquine PDF Hydroxychloroquine effectiveness in reducing symptoms., HERO Trial - Hydroxychloroquine Fails in Hand Osteoarthritis. Chloroquine peak plasma concentraionBiaxin and plaquenil for lymeLong term side effects of plaquenil for rheumatoid arthritisChloroquine maculopathy oct With hydroxychloroquine will be a practical and safe treatment to reduce synovitis and pain. Methods/design HERO is an investigator-initiated, multicentre, randomized, double-blind, placebo-controlled trial. A total of 252 subjects with symptomatic hand OA will be recruited across primary and secondary care sites in the STUDY PROTOCOL Open Access Hydroxychloroquine effectiveness.. Hydroxychloroquine Uses, Dosage & Side Effects -. PATCH study Hydroxychloroquine may prevent recurrence of.. Hydroxychloroquine HCQ is a disease-modifying anti-rheumatic drug DMARD typically used for the treatment of various rheumatic and dermatologic diseases. Three studies of HCQ in OA, including one abstract and one letter, are available and use a wide variety of outcome measures in small patient populations. Instant access to millions of Study Resources, Course Notes, Test Prep, 24/7 Homework Help, Tutors, and more. Learn, teach, and study with Course Hero. Get unstuck. Hydroxychloroquine HCQ is used routinely for treating synovitis in inflammatory arthritis. The primary aim of the HERO RCT was to determine the effectiveness of HCQ as an analgesic treatment for hand OA, and secondarily to determine if synovitis was associated with treatment response, effects on structural progression and cost-effectiveness.