I have been on plaquenil for over a year and a half and methotrexate since September. I get my eyes checked every six months and I am now at once a month on blood work for my liver enzymes (used to be every 2 weeks). I have lupus which mainly affects my joints and skin. One affects your eyes more and one affects your liver more. I would appreciate any comments or advice from everyone. Wannabe Hi, I am on both methotrexate and plaquenil. Wannabe To Be Free To Roam Sorry to hear that you are having a lot of pain with your RA. Plaquenil bledding Plaquenil white hair Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Original Article from The New England Journal of Medicine — Treatment of Rheumatoid Arthritis with Methotrexate Alone, Sulfasalazine and Hydroxychloroquine, or a Combination of All Three Medications Hi everyone! I'm a fairly new methotrexate and hydroxychloroquine user started both in mid-December of last year and am due to go on holiday in Florida on Saturday. There have been a number of coronavirus cases in Florida and two deaths there from the illness. Being on immunosuppressants I'm a little nervous to be travelling there. I wish you well with this decision and the results. Your chances of problems with the methotrexate are a bit larger. deductible (I am at about $2,500 - $3,000 right now). My rheumy recently added Imuran (instead of methotrexate). So, what do yall know about the side effects of both and the benefits of both? Methotrexate and hydroxychloroquine Methotrexate Side-effects, uses, time to work, Treatment of Rheumatoid Arthritis with Methotrexate Alone. Aao 2016 plaquenil Hydroxychloroquine is commonly used alongside other disease-modifying drugs including methotrexate – especially for rheumatoid arthritis. However, some drugs can interact with hydroxychloroquine. Indigestion remedies for example, antacids including some over-the-counter preparations can stop hydroxychloroquine being absorbed. Hydroxychloroquine Side-effects, uses, time to work. Methotrexate and coronavirus rheumatoid. Hydroxychloroquine oral and methotrexate sodium oral Drug.. I'm on methotrexate too now but was on a different immunosuppressant for 18mths before that. Being immune suppressed freaked me out at the start n I thought I'd pick up infection really quickly. I haven't. hubby's had a couple of colds n I've been ok. Im on plaquenil, cellcept AND tacrolimus--finally helping my lupus nephritis and as. Methotrexate Moderate Hydroxychloroquine may reduce the renal clearance of methotrexate; the exact mechanism of this interaction is unknown. The mean AUC of methotrexate was increased 52% and the mean Cmax was reduced 17% when a single dose of methotrexate was given with a dose of hydroxychloroquine 200 mg oral. The study is based on methotrexate sodium and hydroxychloroquine sulfate the active ingredients of Methotrexate and Plaquenil, respectively, and Methotrexate and Plaquenil the brand names. Other drugs that have the same active ingredients e.g. generic drugs are not considered.