I am not shocked about having it just being diagnosed with it. I have seen my rheumatologist for five years and I guess she just thought it was time. Plaquenil side effects eyes symptoms G6pd and hydroxychloroquine Plaquenil ocular toxicity The plaquenil has caused a weight gain of about 20-25 pounds for me. Since I was diagnosed with MCTD a year ago, Plaquenil has been the only medication besides eye supplements, thyroid meds - been stable for years, and most recently Evoxac that I have been given. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Plaquenil; Descriptions. Hydroxychloroquine is used to treat malaria. It is also used to prevent malaria infection in areas or regions where it is known that other medicines eg, chloroquine may not work. She tried to put me on it two years ago even before she diagnosed me because she has always suspected lupus. Anyway, I'm scared to death to take plaquenil but I know that I probably should. Does plaquenil cause you to gain weight Want to know good stuff about plaquenil - HealthBoards, Common and Rare Side Effects for Plaquenil Oral Sketchypharm hydroxychloroquinePrescribing hydroxychloroquine for raHydroxychloroquine discount couponEffects of long term use of plaquenil Signs of heart problems e.g. fast, irregular heartbeat or pulse, chest pain, sudden weight gain, difficulty breathing, leg swelling signs of infection symptoms may include fever or chills, severe diarrhea, shortness of breath, prolonged dizziness, headache, stiff neck, weight loss, or listlessness Plaquenil - Uses, Side Effects, Interactions -. Hydroxychloroquine Oral Route Description and Brand Names - Mayo Clinic. Plaquenil & weight loss Lupus Forums at The Lupus Site. Lucy, meds effect us all differently. Almost any med that can cause weight loss can also cause weight gain. I also find that eating a lot of carbohydrates helps with the GI effects of the plaq and that can contribute to weight gain. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Some of the dosage forms listed on this page may not apply to the brand name Plaquenil. For the Consumer. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine the active ingredient contained in Plaquenil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur.