Chloroquine toxicity

Discussion in 'Northwest Pharmaceuticals Canada' started by ru777ru, 23-Feb-2020.

  1. yus Guest

    Chloroquine toxicity


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Oct 01, 2018 Tamoxifen Concomitant use of Chloroquine with drugs known to induce retinal toxicity such as tamoxifen is not recommended see WARNINGS. Pregnancy See WARNINGS, Usage in Pregnancy. Toxicity. Chloroquine toxicity is rare but has been known to occur when unusually high doses of chloroquine are ingested or after chronic IV administration. Accidental ingestion has also occurred in children. When toxicity is present, the most common symptom is retinal toxicity. Jan 05, 2020 Hydroxychloroquine toxicity Disease Entity. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity. Diagnosis. For retinopathy, patients should be asked about poor central vision. Management. At the first signs of retinal toxicity, hydroxychloroquine should be stopped.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Chloroquine toxicity

    Chloroquine toxicity -, Chloroquine - StatPearls - NCBI Bookshelf

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  7. Side Effects. Drug information provided by IBM Micromedex Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    • Chloroquine Oral Route Side Effects - Mayo Clinic.
    • Hydroxychloroquine toxicity - EyeWiki.
    • Chloroquine Oral Uses, Side Effects, Interactions..

    Effect of four different types of single-dose treatment with chloroquine and with chloroquine and pyrimethamine on Plasmodium falciparum infections in a semi-immune population in northern Nigeria. Retinal toxicity uncommon with chloroquine and even less common with hydroxychloroquine as long as proper dose limits observed; Ophthalmologic monitoring protects against severe toxicity Chloroquine and related quinines have been associated with cases of retinal toxicity, particularly when provided at higher doses for longer times. Accumulation of the drug may result in deposits that can lead to blurred vision and blindness.

     
  8. unonceido Moderator

    Plaquenil (hydroxychloroquine sulfate, Sanofi-Aventis) and the less-used chloroquine are antimalarial drugs with anti-inflammatory properties that are used for the management of a spectrum of inflammatory conditions. Hydroxychloroquine Plaquenil Toxicity and Recommendations. Toxic Retinopathy With Hydroxychloroquine Therapy - JAMA Evaluation of Hydroxychloroquine Retinopathy With Multifocal.
     
  9. BoB4uK Well-Known Member

    Hydroxychloroquine toxicity - EyeWiki Risk for toxicity is least with less than 6.5 mg/kg/day for hydroxychloroquine and 3 mg/kg/day for chloroquine. Patients are at low risk during the first 5 years of treatment. Cumulative use in excess of 250 grams increases the risk for toxic retinopathy. Other risk factors include obesity, kidney or liver disease, older age.

    Aralen, Chloroquine phosphate chloroquine dosing.
     
  10. doorman XenForo Moderator

    Hydroxychloroquine - Wikipedia Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda.

    Hydroxychloroquine - LiverTox - NCBI Bookshelf