In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Plaquenil side effecs Chloroquine tablet Chloroquine resistant malaria treatment Chloroquine autophagy p62 Hui Jen Ding, Alastair K. Denniston, Vijay K. Rao, Caroline Gordon, Hydroxychloroquine-related retinal toxicity, Rheumatology, Volume 55, Issue 6, June 2016, Pages 957–967. High-speed ultra-high-resolution optical coherence tomography findings in hydroxychloroquine retinopathy. The optical coherence tomography angiography findings showed that the parafoveal deep temporal and deep hemi-inferior vascular plexus density was reduced in patients taking hydroxychloroquine for more than 5 years despite having normal perimetry. There is no single best test for detecting hydroxychloroquine toxicity. However, SD-OCT and VF are good screening tests, and FAF and mfERG can help confirm a diagnosis of suspected retinal toxicity from hydroxychloroquine. Early detection of toxicity is critical to prevent permanent visual loss. 1. Jorge A, Ung C, Young L, Melles RB, Choi HK. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Oct findings in plaquenil toxicity Plaquenil Toxicity - OCTMD - Getting Started with OCT, The optical coherence tomography angiography findings of. Chloroquine phosphate and leather coralsOrder aralen malariaBenefits drawbacks hydroxychloroquine The Risk of Retinal Toxicity with Plaquenil. FA imaging, and optical coherence tomography. Recent findings suggest that Plaquenil toxicity can develop among patients that are taking the drug at a daily dose lower than the suggested “safe” dose and/or have been on Plaquenil for shorter than five years. Unfortunately, cessation of. The Risk of Retinal Toxicity with Plaquenil. Retina Today - Imaging in Hydroxychloroquine Toxicity.. Chloroquine and Hydroxychloroquine Toxicity Clinical.. Plaquenil-induced maculopathy is a form of retinal toxicity that is associated with long-term use of of the anti-inflammatory medication plaquenil. The drug-induced maculopathy is associated with the following risk factors Cumulative dose level of 1,000 grams of plaquenil. In Hydroxychloroquine Toxicity Michael F. Marmor, MD Objectives. optical coherence tomography. Patients with early and moderate toxicity had normal examination findings, whereas those with severe toxicity showed bull’s-eye retinal pigment epithelium atrophy. Dence of hydroxychloroquine maculopathy. Table. Clinical, High-Speed Ultra–High-Resolution Optical Coherence Tomography, and Multifocal Electroretinogram Findings From Patients Receiving Hydroxychloroquine Patient No./ Age, y Hydroxychloroquine Dosage, mg/d Diagnosis Treatment, y Symptoms Visual Acuity, OD, OS Color Vision Visual Fields mfERG.