Quinacrine hydrochloride also has the 4-amino quinoline radical but has, in addition, a benzene ring; it is classified as an acridine compound. The 4-amino quinoline radical is present in all antimalarial compounds shown to be effective in the treatment of lupus erythematosus (LE) (Figure). Chloroquine and depression Can plaquenil lower your immune system Quinacrine in the treatment of Cutaneous Lupus Erythematosus Practical Aspects and a Case Series 57 A quinacrine preparation in combination with another antimalarial agent chloroquine or hydroxychloroquine was subsequently marketed for the treatment of discoid lupus. 2 At the end of the 1970s, however, this preparation, along with many other. There are anecdotes about the efficacy of combination antimalarials such as hydroxychloroquine and quinacrine in treating subcutaneous sarcoid, but no studies exist to allow definitive recommendations. Lupus profundus affecting the cheeks. Arthritis inflammation and pain in the joints. Other forms of chronic cutaneous lupus include Lupus profundus is characterized by nodules which can lead to dents in the skin and can be painful. Lupus tumidus refers to a red plaque typically on the face that extends deep in the skin. Its superiority over quinine was established during World War II, when it became the official drug for the treatment of malaria. Quinacrine was introduced for malaria therapy in 1930. Quinacrine and hydroxychloroquine lupus profundus REFERENCES - UpToDate, Lupus Erythematosus Panniculitis - an overview. Plaquenil lethargyHydroxychloroquine plaquenil rheumatoid arthritisHow does the body metabolize plaquenilPlaquenil and heart disease Hydroxychloroquine and chloroquine phosphate have shown beneficial effects in treating discoid lupus erythematosus DLE. Additionally, The antimalarial drugs may prevent the development of systemic lupus erythematosus SLE in patients with DLE, and they might decrease the risk of cardiovascular disease. Alternative therapies, anecdotal reports, and small, open-label trials as reported by. Discoid Lupus Erythematosus Medication Antimalarial.. Rashes, Skin Care and Cutaneous Lupus What You Should Know. Treatment of Cutaneous Lupus Erythematosus. Treatment of recalcitrant cutaneous lupus erythematosus CLE is challenging. It was revised and improved in 2010 to take the different subtypes of CLE – especially lupus erythemathosus profundus and LET – into account 4. Ceribelli A, Zane C, Cattaneo R, et al. Treatment of lupus skin involvement with quinacrine and. One of the key goals of the Lupus Foundation of America Foundation is to ensure people with lupus have access to the care and treatments they need. Recently, access to a few vital treatments has been challenging to obtain, specifically access to quinacrine, hydroxychloroquine, and Benlysta®. In. Aug 21, 2018 Hydroxychloroquine is the drug of choice when a systemic agent is needed for discoid lupus erythematosus DLE. Chloroquine is second-line antimalarial therapy. Chloroquine and hydroxychloroquine should not be used in combination due to the increased risk of ocular toxicity.