But there also has to be something negative going on if it's making my hair fall out! mshistory - I know what you're saying is ALL true. I won't let things go to long like this, but I am hoping this is just some sort of rebound effect and that things will level off. I need to find a new one, but with 2 small kids and work full time, who has the time?! like i said i have super thick hair so i still have have a good amount but its def not super super thick like it once was. for those of you losing hair loss-lets be like Dolly Parton and all these other stars and wear wigs! It was making me feel better in other ways -no doubt. As for the psychologist, I did try that over the summer, but was not impressed by the one I was going to. If you remember, most wait at least 3 months before they even see any improvement. i lost a bunch of hair the 1st 4 months and now it has steadied off... along with the extreme dry patchy skin that bleads and all my lovely knew wrinkles along my eyes from doing warm compresses , massage and drops!!! this disease sure takes a toll52 yr old Sj S, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) Ig G def., Cushing's, Asthma, Gastroparesis. Dose of chloroquine to inhibit autophagy Nf54 chloroquine ic50 Hydroxychloroquine mechanism of action arthritis Taking Plaquenil long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking Plaquenil and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Anita- I had always heard that too - that even if you stopped it, it would take a long time before it was out of your system. I still believe this to be true, but I am convinced now that plaquenil must have multiple modes of action, one being long term effects, and one being something happening in the short term. Children should not take hydroxychloroquine for long-term therapy. Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to hydroxychloroquine. If you are taking hydroxychloroquine for a long period of time, your doctor will recommend frequent eye exams. I thought methotrexate was stronger and had harder side effects??? Being 32 and feeling like I'm way too young to be dealing with any of this but trying to find my way through it BTW, seeing a psychiatrist and dealing with my depression and anxiety seriously saved my life. And your hair is growing back even while you're still on 200 a day? I wonder if what you're noticing is really the change in dose. You need to decided what is more important..or health.52 yr old Sj S, APS w/strokes, Autonomic Neuropathy, PN, Nephrogenic DI, (CVID) Ig G def., Cushing's, Asthma, Gastroparesis. Meds: IVIG & pre-meds, Arixtra, Aspirin, Plaquenil, Cardizem, Toprol XL, Domperidone, Nexium, Midodrine, Symbicort, Fentanyl, Percocet, Zofranthats the hard part---you never know.. If you feel really overwhelmed by all of this, it might be something to consider. now i still have quite a bit of hair but plaquenil made me lose a lot.. I'm wondering if 400 a day is just too much for some of us to handle? I say this because Plaquenil has a chemical half-life of 30-60 days (you can confirm this on wiki or RX info on the drug)--so it takes a LONG time to get out of your system..long for you to notice changes in days. whenever i take something new i think i get a weird side effect--but then again could it just be part of a flare...ughhhhh.. How long is plaquenil in your system Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Let me tell you what weaning down from Plaquenil is like. Reducing plaquenilPrimaquine and chloroquineCarbamazepine with chloroquinePlaquenil generic goodrx I wonder if what you're noticing is really the change in dose. I say this because Plaquenil has a chemical half-life of 30-60 days you can confirm this on wiki or RX info on the drug--so it takes a LONG time to get out of your system.long for you to notice changes in days. Let me tell you what weaning down from Plaquenil. Hydroxychloroquine MedlinePlus Drug Information. How long does Hydroxychloroquine stay in your system?. How long does it take for Plaquenil to leave your system. Asked by Joyceagnes Updated 6 November 2016 Topics plaquenil, multiple sclerosis, systemic lupus erythematosus, system I came across this page having the same question. How long does it take for Plaquenil to leave your system after discontinuing use. However, I do not want to stop taking it because of terrible side effects listed by other users of the med. I love this drug. I have never felt as good as I do now. Montui, glad your going ok. I had my 2nd rhuemy appt. I just started plaquenil, this is my 2nd day. I sure hope this will work for me. I have to take it for 3 months and go back for check up and then i will start the metho.