Estrogen use should be discontinued unless its need outweighs its adverse effects on porphyrin metabolism. After achievement of remission, estrogen therapies may be cautiously reinstituted; however, the duration of remissions may be shortened. Hydroxychloroquine lyme disease Chloroquine cancer stem cell Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment of Patients With Porphyria Cutanea Tarda Low-dose hydroxychloroquine or chloroquine. These drugs are recommended for patients in whom phlebotomy is contraindicated, difficult, or poorly tolerated. Singal AK, Kormos-Hallberg C, Lee C, et al. Low-dose hydroxychloroquine is as effective as phlebotomy in treatment of patients with porphyria cutanea tarda. Porphyria cutanea tarda may appear for the first time in patients with end-stage renal disease after several months of long-term dialysis. Anuric individuals can be readily diagnosed by assaying a plasma or serum specimen for the characteristic elevated levels of polycarboxylated porphyrins. If symptoms recur, re-treatment can restore remissions. Remissions may last from several months to many years. Low-dose hydroxychloroquine role in porphyria STUDIES ON LOW DOSE CHLOROQUINE THERAPY AND THE ACTION OF CHLOROQUINE., Porphyria cutanea tarda - Approach BMJ Best Practice Plaquenil vs methotrexate for raPlaquenil aptt testCan you abruptly stop hydroxychloroquine Read "Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in Treatment of Patients With Porphyria Cutanea Tarda, Clinical Gastroenterology and Hepatology" on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. Low-Dose Hydroxychloroquine Is as Effective as Phlebotomy in. - DeepDyve. Porphyria Cutanea Tarda Treatment & Management Medical Care, Surgical.. Hydroxychloroquine and Phlebotomy for Treating Porphyria Cutanea Tarda.. BACKGROUND & AIMS Porphyria cutanea tarda PCT is an iron-related disorder caused by reduced activity of hepatic uroporphyrinogen decarboxylase; it can be treated by phlebotomy or low doses of hydroxychloroquine. Porphyria cutanea tarda, the most common type of porphyria worldwide, is caused by a deficiency of uroporphyrinogen decarboxylase, a crucial enzyme in heme biosynthesis, which results in an accumulation of photosensitive byproducts, such as uroporphyrinogen, which leads to the fragility and blistering of sun-exposed skin. Porphyria cutanea tarda PCT is an iron-related disorder caused by reduced activity of hepatic uroporphyrinogen decarboxylase; it can be treated by phlebotomy or low doses of hydroxychloroquine.