It regulates the activity of the immune system, which may be overactive in some conditions. Hydroxychloroquine can modify the underlying disease process, rather than simply treating the symptoms. Lupus and plaquenil problems Plaquenil for worms Can you drink alcohol while taking Plaquenil? I don't drink everyday, but have had some drinks while on NSAIDS and Prednisone and have not had any bad effects. I also take Methotrexate, along with Plaquenil plus many others and I don't drink any alcohol. Then again, this is an individual decision. I would run it by my doctor and see if they thought it was ok. You then could either drink a little wine, or abstain. I have read where a glass of wine OCCASIONALLY wouldn't hurt. First and foremost, mixing alcohol and pain medicines can be fatal. If you’re taking medications to manage your pain, talk to your doctor or pharmacist about any reactions that may result from drinking alcohol. If you are taking methotrexate, leflunomide, mycophenolate mofetil, or other drugs that are metabolized in the liver, you should not. Hydroxychloroquine is often taken in combination with other drugs such as methotrexate. Over the long term hydroxychloroquine can reduce pain, swelling and joint stiffness. It may be as long as 12 weeks before you notice the benefits. Can you drink alcohol when your taking plaquenil Can i Drink Alcohol While Taking Plaquenil - JustAnswer, Plaquenil and drinking - Sjogren's World Does prednisone and plaquenil work for ankylosing spondylitis Talk to your doctor if you are using marijuana cannabis. Alcohol can also increase your risk of liver problems while you are taking this drug. This medication may make you more sensitive to the sun. Plaquenil Oral Uses, Side Effects, Interactions, Pictures.. Thinking about drinking? Read this first Lupus.. Thinking about drinking? Read this first Lupus Foundation.. Sep 26, 2011 I was researching on wine alcohol use while on Plaquenil and I'm a bit confused. I'm also taking Naturethoid. I love wine, but if I have to give it up, I would for my health. I was wondering if anyone else has social drinks while on these meds. I know alcohol dehydrates you, I do drink lots of water. Thanks in advance for your help! Always follow the advice of your healthcare practitioner or pharmacists and never assume – ask whether or not you can safely drink when taking your meds. Stop drinking at least two hours before bedtime – remember, contrary to belief, alcohol acts as a stimulant. Keep hydrated. If you are drinking, make sure to have a glass of water nearby. Since a number of medical conditions can be worsened with the use of Plaquenil, warnings and precautions for the medication should be discussed with your healthcare provider before treatment begins. Let your healthcare provider know if you have psoriasis, liver disease, alcoholism, or a G-6-PD deficiency before using Plaquenil.