Derm Net NZ Medical Editor: Dr Delwyn Dyall-Smith, Dermatologist, Wagga Wagga, NSW, Australia. However, following an identical dose of hydroxychloroquine and chloroquine, tissue levels of chloroquine are 2.5 times those of hydroxychloroquine. Derm Net NZ Editor in Chief: Adjunct Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. Hydroxychloroquine is preferred due to its safer profile. Plaquenil side effects liver Plaquenil not sleeping Plaquenil toxicty Hydroxychloroquine dangers Multiple pathologic mechanisms are responsible for drug-induced pigmentation disorders. Compared with the immunological etiology underlying many drug allergies, most cases of pharmacologic pigmentation are not immunologically mediated. The pigmentation resolved in two patients following chloroquine withdrawal despite being substituted by hydroxychloroquine. Hence, hydroxychloroquine may score over chloroquine not only with reference to ocular toxicity 9, but also with reference to cutaneous toxic-ity, for its long term use in patients suffering from con- Hydroxychloroquine Plaquenil® is a 4-amino-quinoline antimalarial medication that is widely used to treat systemic lupus erythematosus SLE, rheumatoid arthritis, and related inflammatory and dermatological conditions. It is a hydroxylated version of chloroquine, with a similar mechanism of action. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. If there is a of hydroxychloroquine, although studies have not usually confirmed this clinical impression. Chloroquine pigmentation Hydroxychloroquine-induced Hyperpigmentation of the Skin., Hyperpigmentation of the Skin Following Chloroquine. Retinal deposits plaquenilG6pd hydroxychloroquineAao 2016 plaquenilHydroxychloroquine zentiva Nov 01, 2019 Oral pigmentation is a relatively common condition that may involve any portion of the oral cavity. Multiple causes are known, and they may range from simple iatrogenic mechanisms, such as implantation of dental amalgam, to complex medical disorders, such as Peutz-Jeghers syndrome. Disorders of Oral Pigmentation Background, Pathophysiology.. Hydroxychloroquine DermNet NZ. Chloroquine –Induced Hair Depigmentation - TB Di Giacomo.. Chloroquine is a 4-aminoquinoline with antimalarial, anti-inflammatory, and potential chemosensitization and radiosensitization activities. Although the mechanism is not well understood, chloroquine is shown to inhibit the parasitic enzyme heme polymerase that converts the toxic heme into non-toxic hemazoin, thereby resulting in the accumulation of toxic heme within the parasite. Use of antimalarials ie, quinacrine, chloroquine, hydroxychloroquine HCQ can induce tissue pigmentation in a variety of organs, including skin, joint tissue, trachea, and cartilage in the nose and ears. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. It is also being used as an experimental treatment for SARS-CoV-2.