Hemozoin chloroquin

Discussion in 'Trust Pharmacy Canada' started by KufinskII, 05-Mar-2020.

  1. SLIM9093 New Member

    Hemozoin chloroquin

    These hematophagous organisms such as Malaria parasites (Plasmodium spp.), Rhodnius and Schistosoma digest haemoglobin and release high quantities of free heme, which is the non-protein component of hemoglobin. Heme is a prosthetic group consisting of an iron atom contained in the center of a heterocyclic porphyrin ring.

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    Chloroquin có tác dụng diệt ký sinh trùng sốt rét có thể do các cơ chế sau + Ức chế quá trình polyme hoá, làm thiếu hemozoin và tích luỹ hem gây độc cho ký sinh trùng. + Tạo phức hợp chloroquin - FP IX gây tiêu huỷ màng tế bào và diệt ký sinh trùng. Chloroquine CQ is used to prevent and treat malaria and amebiasis, while hydroxychloroquine HCQ, a less toxic metabolite of chloroquine, is used to treat rheumatic diseases such as systemic lupus erythematosus SLE, rheumatoid arthritis RA, juvenile idiopathic arthritis JIA and Sjogren's syndrome. The mutants produce little or no hemozoin Hz, the detoxification by-product of Hb degradation. Further, they are resistant to chloroquine, an antimalarial drug that interferes with Hz formation, but their sensitivity to artesunate, also thought to be dependent on Hb degradation, is retained.

    In malaria parasites, hemozoin is often called malaria pigment. Free heme is toxic to cells, so the parasites convert it into an insoluble crystalline form called hemozoin.

    Hemozoin chloroquin

    Chloroquine and hemozoin. - CAB Direct, Chloroquine And Hydroxychloroquine Toxicity - StatPearls.

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  5. Uses of Chloroquine It is used to treat or prevent malaria. It is used to treat a type of bowel infection. It may be given to you for other reasons.

    • Chloroquine Indications, Side Effects, Warnings -.
    • Replication of Plasmodium in reticulocytes can occur..
    • Malarial hemozoin from target to tool. Semantic Scholar.

    Chloroquine forms a drug-hemozoin complex, and this complex caps the polymerizing chain, thereby preventing additional polymerization. Along with the prevention of polymerization, the free heme accumulates in the food vacuole, exerting its toxic effects on the parasite. Chloroquine also functions as an anti-autoimmune therapy. Chloroquine caps hemozoin molecules to prevent further biocrystallization of heme, thus leading to heme buildup. Chloroquine binds to heme or FP to form what is known as the FP-Chloroquine complex; this complex is highly toxic to the cell and disrupts membrane function. In contrast chloroquine-resistant P. falciparum exposed to 100 ng of chloroquine per ml incorporated 630 pmol of FP into /3-hematin. Thus, chloroquine inhibits hemozoin production in chloroquine-susceptible P. falciparum but not in chloroquine-re- sistant P. falciparum.

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