Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Plaquenil and scleroderma Chloroquine and digoxin Plaquenil helps spasms Chloroquine belong to what drug family Previously diagnosed plaquenil toxicity. Stopped taking drug 7 years prior Vision loss continues to progress Wants to measure change from last exam with mfERG in 2002. Harbors deep seeded anger for old ophthalmologist but seems to like me. The patterns of mfERG loss seen herein at various stages of toxicity are similar to what has been observed previously. 4,12 Lai et al 17 suggested that mfERG may show gradual signal loss that correlates with dose and field sensitivity, but it remains to be shown whether such changes can be recognized clinically and prospectively. Multifocal electroretinography mfERG may be the most sensitive test for early toxicity, although it may not be readily available in all locations. The new guidelines recommend 10-2 automated perimetry, plus at least one of SD-OCT, FAF, or mfERG if they are available. These tests should be performed at baseline and at each subsequent evaluation. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Mferg plaquenil Early Plaquenil Toxicity Detected without Bull’s Eye., Comparison of Screening Procedures in Hydroxychloroquine Toxicity Id 10 code for plaquenilPlaquenil bone pain This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. Hydroxychloroquine-Induced Retinal Toxicity - American.. Retinal Physician - New Screening Guidelines for.. Taking Plaquenil for Rheumatoid Arthritis. What is Plaquenil? Plaquenil hydroxychloroquine is a medication most known for its original purpose of treating or preventing malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Find patient medical information for Plaquenil Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says.