She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation. Plaquenil did not work for me Plaquenil and liver toxicity Chloroquine package insert Screening for chloroquine and hydroxychloroquine retinopathy. Ophthalmology. 92 2011;1182415-22. 93 5. Marmor MF, Kellner U, Lai TY, Melles RB, Mieler WF, American Academy of O. 94 Recommendations on Screening for Chloroquine and Hydroxychloroquine Retinopathy 2016 95 Revision. Ophthalmology. 2016. 96 6. Plaquenil Toxicity Screening Plaquenil Toxicity Screening Plaquenil Toxicity Screening Hydroxychloroquine Sulphate Plaquenil medication has been effectively used for many years for a variety of infectious and autoimmune conditions, including rheumatoid Arthritis RA and Systemic Lupus Erythematosus SLE. On rare occasion, and usually after many years, Plaquenil can damage the central. Pearce FA, Grainge MJ, King AJ, Lanyon PC. O39 Implementing screening for hydroxychloroquine ocular toxicity how big is the problem? Epidemiology of hydroxychloroquine prescriptions in the UK. Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use. Plaquenil retinopathy screening Hydroxychloroquine - Wikipedia, Plaquenil Toxicity Screening - Retina Group of New York Hydroxychloroquine cardiac protective Currently, one of the primary functional screening tests recommended for the evaluation of Plaquenil retinal toxicity is 10-2 white stimulus automated visual fields; however, research shows Asian patients benefited from 24-2 or 30-2 visual fields, given that toxicity often manifests changes beyond the macula in these patients. 9 Because spectral-domain optical coherence tomography SD-OCT is readily accessible and able to detect early structural damage prior to clinical funduscopic findings. How to Succeed in Plaquenil Screenings. Hydroxychloroquine baseline retinopathy screening when to.. My Take on New Ocular Screening Guidelines for Plaquenil.. Apr 17, 2017 The quinine family of drugs has been used for a variety of conditions, and Hydroxychloroquine Sulphate Plaquenil is a valuable drug for the treatment of certain auto-immune collagen-vascular disease processes. Rheumatoid Arthritis RA and Systemic Lupus Erithematosus SLE are conditions for which Hydroxychloroquine has been found to be of help. In 2011 the American Academy of Ophthalmology published new clinical guidelines for appropriate annual screenings for those patients taking Plaquenil. These guidelines are much different from the previous 2002 recommendations, and many practicing doctors were trained with the 2002 guidelines in mind. Given the initial low risk of HCQ or CQ retinopathy, with a proper dose and in the absence of major risk factors, annual screening can be deferred until there has been 5 years of exposure. Screening should begin sooner if the risk is high Table 1.