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For some preparations, you should wait 20-30 minutes after cleaning your face before applying this medication. Consult the label directions, the Patient Information Leaflet, or your pharmacist if you have any questions. Do not apply to the inner lip area or inside the nose/mouth. Retin-A and Retin-A Micro are both topical prescription medications that your dermatologist may prescribe to treat your acne. Because they have nearly identical names and are manufactured by the same company, you may wonder if they're the same medication. Tretinoin is a topical retinoid, meaning it's a medication derived from vitamin A. Other topical medications that contain tretinoin include Avita, Altinac, Tretin-X, Renova (mainly prescribed as an anti-wrinkle medication), and Ziana. Because they contain the same active ingredient, Retin-A and Retin-A Micro work in essentially the same way. Both medications work to speed up cell turnover rates. 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