Generic Name: Azithromycin (multiple manufacturers) Common Brand Name: Zithromax (Pfizer — U. S.) Popularity: 11th most commonly prescribed drug between 2002 — 2007 (U. S.) Class: Macrolide antibiotic Treatment Uses — For treatment of bacterial infections. Azithromycin has distinct advantages over earlier macrolides such as erythromycin that include better tolerance, better tissue penetration and more favorable pharmacokinetics. Because azithromycin can be dosed once daily, it improves patient compliance — a leading cause of antibiotic failures. Macrolides act primarily against streptococci and staphylococci, and are often used to treat these bugs in patients intolerant of penicillins. The therapeutic uses for azithromycin are broad and continually changing. buy erythromycin stearate Each film-coated tablet contains 250 mg azithromycin (as azithromycin monohydrate) Excipient(s) with known effect: Each film-coated tablet contains 6.84 mg lactose (as lactose monohydrate) and 0.57 mg (0.025 mmol) sodium. Azithromycin is indicated for the treatment of the following infections, when caused by microorganisms sensitive to azithromycin (see section 4.4 and 5.1): - acute bacterial sinusitis (adequately diagnosed) - acute bacterial otitis media (adequately diagnosed) - pharyngitis/tonsillitis - acute exacerbation of chronic bronchitis (adequately diagnosed) - mild to moderately severe community-acquired pneumonia - skin and soft tissue infections - uncomplicated Chlamydia trachomatis urethritis and cervicitis Consideration should be given to official guidance on the appropriate use of antibacterial agents. Posology Adults In uncomplicated Chlamydia trachomatis urethritis and cervicitis the dosage is 1,000 mg as a single oral dose. For all other indications the dose is 1,500 mg, to be administered as 500 mg per day for three consecutive days. Older people The same dose range as in younger patients may be used in the elderly. Children Azithromycin film-coated tablets should only be administered to children weighing more than 45 kg when normal adult dose should be used. For children under 45 kg other pharmaceutical forms of azithromycin, e.g. Patients with renal impairment: No dose adjustment is necessary in patients with mild to moderate renal impairment (GFR 10-80 ml/min) (see section 4.4). Patients with hepatic impairment: A dose adjustment is not necessary for patients with mild to moderately impaired liver function (see section 4.4). Where can i buy accutane in stores Sildenafil india Dec 11, 2018. Azithromycin Mechanisms of Action and Their Relevance for. The exact mechanism of macrolide clinical bene- fits in inflammatory lung. metoprolol pharmacokinetics Of the genes involved in the transport, metabolism and mechanism of action of the macrolide antibiotics erythromycin, clarithromycin, and azithromycin. Zithromax, Azithrocin, others Synonyms 9-deoxy-9α-aza-9α-methyl-9α-homoerythromycin A. Azithromycin is an antibiotic useful for the treatment of a number of bacterial infections. Mechanism of action. Azithromycin prevents bacteria from growing by interfering with their protein synthesis. Azithromycin tablets can be applied for the treatment of the following infections, when caused by microorganisms sensitive to azithromycin (see sections 4.4 and 5.1): - acute bacterial sinusitis (adequately diagnosed) - acute bacterial otitis media (adequately diagnosed) - pharyngitis, tonsillitis - acute exacerbation of chronic bronchitis (adequately diagnosed) - mild to moderately severe community acquired pneumonia - skin and soft tissue infections - uncomplicated Chlamydia trachomatis urethritis and cervicitis Considerations should be given to official guidance on the appropriate use of antibacterial agents. Adults In uncomplicated Chlamydia trachomatis urethritis and cervicitis the dose is 1000 mg as a single oral dose. For all other indications the dose is 1500 mg, to be administered as 500 mg per day for three consecutive days. As an alternative the same total dose (1500 mg) can also be administered over a period of five days with 500 mg on the first day and 250 mg on the second to the fifth day. Elderly people The same dose as in adult patients is used for elderly people. Since older people can be patients with ongoing proarrhythmic conditions a particular caution is recommended due to the risk of developing cardiac arrhythmia and torsades de pointes (see section 4.4). Paediatric population Azithromycin tablets should only be administered to children weighing more than 45 kg when normal adult dose should be used. Azithromycin is indicated for the treatment of the following infections when known or likely to be due to one or more susceptible microorganisms (see section 5.1): - bronchitis - community-acquired pneumonia - sinusitis - pharyngitis/tonsillitis (see section 4.4 regarding streptococcal infections) - otitis media - skin and soft tissue infections - uncomplicated genital infections due to Chlamydia trachomatis and Neisseria gonorrhoeae. Considerations should be given to official guidance regarding the appropriate use of antibacterial agents. Zithromax capsules should be given as a single daily dose. In common with many other antibiotics Zithromax Capsules should be taken at least 1 hour before or 2 hours after food. Children over 45 kg body weight and adults, including elderly patients: The total dose of azithromycin is 1500 mg which should be given over three days (500 mg once daily). In uncomplicated genital infections due to Chlamydia trachomatis, the dose is 1000 mg as a single oral dose. For susceptible Neisseria gonorrhoeae the recommended dose is 1000 mg or 2000 mg of azithromycin in combination with 250 mg or 500 mg ceftriaxone according to local clinical treatment guidelines. Zithromax mode of action Azithromycin, clarithromycin, and telithromycin - UpToDate, Macrolide Antibiotic Pathway, Pharmacokinetics/Pharmacodynamics. Prednisone meaning Is it ok to buy cialis online Mode of Action of Macrolide Antibiotics. Zithromax®, Zitromax®, Sumamed® clarithromycin Biaxin® dirithromycin Dynabac®. Macrolide antibiotics can cause irritation to the stomach. * The information in this article is not meant to be used for self-diagnosis or treatment of illness. If Mode of Action MOA of Macrolide Antibiotics Azithromycin - Wikipedia Zithromax - FDA prescribing information, side effects and uses Find patient medical information for Azithromycin Oral on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings. sildenafil 20 mg cost Sep 1, 2016. Azithromycin became one of the best-selling branded antibiotics worldwide. Structural. Macrolides and Their Mode of Action as Anti-Infectives. Pharmacodynamics Mode of Action Azithromycin is the first of a subclass of macrolide antibiotics, known as azalides, and is chemically different from erythromycin. Chemically it is derived by insertion of a nitrogen atom into the lactone ring of erythromycin A.